rs4147929
|
|
Alzheimer's Disease
|
|
0.860 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.
|
31473137 |
2019 |
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Thus, in African Americans the interactive effects of ABCA7 rs3764650 and aerobic fitness likely compound overall ABCA7-related AD risk, and may contribute to health disparities whereby African Americans are at a higher risk for dementia, with double the prevalence of AD.
|
31024289 |
2019 |
rs115550680
|
|
Alzheimer's Disease
|
|
0.830 |
GeneticVariation
|
BEFREE |
While ABCA7 rs115550680 has been linked to the development of late-onset AD in African Americans, no association between ABCA7 variant rs3764650 and AD has been found in this population.
|
31024289 |
2019 |
rs3752246
|
|
Alzheimer's Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Our case-control study (416 AD patients and 302 controls) provides further data on the rs3752246 polymorphism in AD in the Hungarian population that has not been investigated so far regarding the ABCA7 gene variants.
|
30717989 |
2019 |
rs4147929
|
|
Alzheimer's Disease
|
A |
0.860 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
rs3752241
|
|
Alzheimer's Disease
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
rs111278892
|
|
Alzheimer's Disease
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The associations of rs3764650 with CSF Aβ<sub>1-42</sub>, t-tau and p-tau were analyzed in non-dementia AD, including preclinical and prodromal AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.
|
30596067 |
2018 |
rs4147929
|
|
Alzheimer's Disease
|
|
0.860 |
GeneticVariation
|
BEFREE |
To evaluate AD risk conferred by <i>ABCA7</i> rs4147929:G>A and <i>CD33</i> rs3865444:C>A, we used a large Spanish population (1796 AD cases, 2642 controls).
|
29872490 |
2018 |
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Three common loci were confirmed to increase the risk of AD (rs3764650: OR = 1.20, 95% CI = 1.16-1.24; rs3752246: OR = 1.13,95% CI = 1.08-1.19; rs4147929: OR = 1.17, 95% CI = 1.10-1.24), but the associations varied among the different races.
|
29782324 |
2018 |
rs4147929
|
|
Alzheimer's Disease
|
|
0.860 |
GeneticVariation
|
BEFREE |
Three common loci were confirmed to increase the risk of AD (rs3764650: OR = 1.20, 95% CI = 1.16-1.24; rs3752246: OR = 1.13,95% CI = 1.08-1.19; rs4147929: OR = 1.17, 95% CI = 1.10-1.24), but the associations varied among the different races.
|
29782324 |
2018 |
rs3752246
|
|
Alzheimer's Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Three common loci were confirmed to increase the risk of AD (rs3764650: OR = 1.20, 95% CI = 1.16-1.24; rs3752246: OR = 1.13,95% CI = 1.08-1.19; rs4147929: OR = 1.17, 95% CI = 1.10-1.24), but the associations varied among the different races.
|
29782324 |
2018 |
rs4147929
|
|
Alzheimer's Disease
|
|
0.860 |
GeneticVariation
|
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
rs3795065
|
|
Alzheimer's Disease
|
|
0.700 |
GeneticVariation
|
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
rs3752231
|
|
Alzheimer's Disease
|
|
0.700 |
GeneticVariation
|
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
ABCA7 rs3764650 polymorphism was significantly associated with A</span>D risk (OR=1.21, 95% CI 1.16-1.26, P<0.00001; I2=5%).
|
29441941 |
2017 |
rs4147929
|
|
Alzheimer's Disease
|
|
0.860 |
GeneticVariation
|
BEFREE |
Including 178,304 individuals, the meta-analyzed odds ratio for Alzheimer's disease per one allele <i>ABCA7</i> rs4147929 increase was 1.15 (1.12-1.18).
|
29376091 |
2018 |
rs200538373
|
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In particular, the rare AD associated polymorphism rs200538373 was associated with altered ABCA7 exon 41 splicing and an AD risk odds ratio of ∼1.9.
|
28655137 |
2017 |
rs200538373
|
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the association of Alzheimer's disease (AD)-related rare variants APP A673T and ABCA7 rs200538373-C with the levels of β-amyloid (Aβ) and parameters of metabolic and cardiovascular health in a population-based cohort of healthy middle-aged and elderly men.
|
28556232 |
2017 |
rs4147929
|
|
Alzheimer's Disease
|
|
0.860 |
GeneticVariation
|
BEFREE |
Brain regions most significantly associated with AD risk variants were the left postcentral gyrus with ABCA7 (rs4147929, p = 4.45 × 10<sup>-6</sup>), right superior frontal gyrus by ZCWPW1 (rs1476679, p = 5.12 × 10<sup>-6</sup>), and right postcentral gyrus by APOE (p = 6.91 × 10<sup>-6</sup>).
|
27718423 |
2016 |
rs72973581
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
This locus harbors a low-frequency coding variant (p.G215S, rs72973581, minor allele frequency = 4.3%) conferring a modest but statistically significant protection against AD (p-value = 0.024, odds ratio = 0.57, 95% confidence interval = 0.41-0.80).
|
27289440 |
2016 |
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A comprehensive literature search for studies involving the association between gene polymorphisms and AD was performed, and we finally selected 3 genes (4 polymorphisms) for the meta-analysis: ABCA7 (rs3764650), CD33 (rs3865444), and TOMM40 (rs157580, rs2075650).
|
26795201 |
2016 |
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
An intronic low-frequency variant rs78117248 (minor allele frequency 3·8% in 58 patients with Alzheimer's disease and in controls 1·8% in 28 controls) showed strongest association with Alzheimer's disease (odds ratio 2·07, 95% CI 1·31-3·27; p=0·0016), and remained significant after conditioning for the GWAS top single nucleotide polymorphisms rs3764650, rs4147929, and rs3752246 (2·00, 1·22-3·26; p=0·006).
|
26141617 |
2015 |
rs4147929
|
|
Alzheimer's Disease
|
|
0.860 |
GeneticVariation
|
BEFREE |
An intronic low-frequency variant rs78117248 (minor allele frequency 3·8% in 58 patients with Alzheimer's disease and in controls 1·8% in 28 controls) showed strongest association with Alzheimer's disease (odds ratio 2·07, 95% CI 1·31-3·27; p=0·0016), and remained significant after conditioning for the GWAS top single nucleotide polymorphisms rs3764650, rs4147929, and rs3752246 (2·00, 1·22-3·26; p=0·006).
|
26141617 |
2015 |
rs3752246
|
|
Alzheimer's Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
An intronic low-frequency variant rs78117248 (minor allele frequency 3·8% in 58 patients with Alzheimer's disease and in controls 1·8% in 28 controls) showed strongest association with Alzheimer's disease (odds ratio 2·07, 95% CI 1·31-3·27; p=0·0016), and remained significant after conditioning for the GWAS top single nucleotide polymorphisms rs3764650, rs4147929, and rs3752246 (2·00, 1·22-3·26; p=0·006).
|
26141617 |
2015 |